Acetyl chloride → HCID 67955225, compound

HRID 1423573Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[NH:19][C:18]([CH3:20])=[C:17]([C:21]([NH:23][CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[O:22])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2].[C:30](Cl)(=[O:32])[CH3:31]>>[C:30]([N:27]1[CH2:26][CH2:25][CH:24]([NH:23][C:21]([C:17]2[C:13]3[N:14]=[CH:15][N:16]=[C:11]([C:5]4[CH:6]=[C:7]([F:10])[CH:8]=[CH:9][C:4]=4[O:3][CH2:1][CH3:2])[C:12]=3[NH:19][C:18]=2[CH3:20])=[O:22])[CH2:29][CH2:28]1)(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 67956010HCID 67956010, compound

Product 1

HCID 67955225HCID 67955225, compound

Procedure

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide (example D.f17) and commercially acetyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-7c29384ab145456a83e2dda52fe45af3
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

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