Propionyl chloride → HCID 67956676, compound

HRID 1423574Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[NH:19][C:18]([CH3:20])=[C:17]([C:21]([NH:23][CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[O:22])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2].[C:30](Cl)(=[O:33])[CH2:31][CH3:32]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[C:12]2[NH:19][C:18]([CH3:20])=[C:17]([C:21]([NH:23][CH:24]3[CH2:25][CH2:26][N:27]([C:30](=[O:33])[CH2:31][CH3:32])[CH2:28][CH2:29]3)=[O:22])[C:13]=2[N:14]=[CH:15][N:16]=1)[CH3:2]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 67956010HCID 67956010, compound

Product 1

HCID 67956676HCID 67956676, compound

Procedure

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide (example D.f17) and commercially propionyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-f131f35d8d3049ec9b350d3e4b79aa03
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

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