Acetyl chloride → HCID 50991053, compound

HRID 1423610Notes

Reaction equation

Cl.[CH:2]1([CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=2[C:17]2[C:18]3[NH:25][C:24]([CH3:26])=[C:23]([C:27]([NH:29][CH:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)=[O:28])[C:19]=3[N:20]=[CH:21][N:22]=2)[CH2:4][CH2:3]1.[C:36](Cl)(=[O:38])[CH3:37]>>[C:36]([N:33]1[CH2:32][CH2:31][CH:30]([NH:29][C:27]([C:23]2[C:19]3[N:20]=[CH:21][N:22]=[C:17]([C:8]4[CH:9]=[C:10]([C:13]([F:15])([F:14])[F:16])[CH:11]=[CH:12][C:7]=4[O:6][CH2:5][CH:2]4[CH2:3][CH2:4]4)[C:18]=3[NH:25][C:24]=2[CH3:26])=[O:28])[CH2:35][CH2:34]1)(=[O:38])[CH3:37]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 67956261HCID 67956261, compound

Product 1

HCID 50991053HCID 50991053, compound

Procedure

Starting from 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f31) and commercially available acetyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-792e0f69786a411ba606020efe79c638
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

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