Acetoxyacetyl chloride → HCID 67955048, compound

HRID 1423722Notes

Reaction equation

Cl.[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]1[C:13]2[NH:20][C:19]([CH3:21])=[C:18]([C:22]([NH:24][CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[O:23])[C:14]=2[N:15]=[CH:16][N:17]=1)[CH3:3].C([O:34][CH2:35][C:36](Cl)=[O:37])(=O)C>>[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]1[C:13]2[NH:20][C:19]([CH3:21])=[C:18]([C:22]([NH:24][CH:25]3[CH2:26][CH2:27][N:28]([C:35](=[O:34])[CH2:36][OH:37])[CH2:29][CH2:30]3)=[O:23])[C:14]=2[N:15]=[CH:16][N:17]=1)[CH3:3]

Participants

Reactant 2

HCID 26297Acetoxyacetyl chloride

HCID 67956009HCID 67956009, compound

Product 1

HCID 67955048HCID 67955048, compound

Procedure

Starting from 4-(2-ethoxy-5-fluorophenyl)-6-methyl-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f17) and commercially available 2-chloro-2-oxoethyl acetate the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-c928c6a793ee40819b07a7edb8bb6223
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

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