Potassium Carbonate → HCID 71116054, compound

Participants

Reaction Steps

To a yellow solution containing 7-(aminomethyl)-7-ethyl-3-neopentyl-1-oxa-3-azaspiro[4.5]decan-2-one (0.195 g, 0.690 mmol) and 3-fluoro-4-nitrobenzonitrile (0.126 g, 0.760 mmol) in MeCN (6.90 ml) was added potassium carbonate (0.191 g, 1.381 mmol). The reaction was stirred at rt for 16 h. The reaction was filtered through a frit, and the filtrate was concentrated onto florisil for purification on a 12 g silica gel column (5-25% EtOAc/hexanes, 30 min gradient; 25-55% EtOAc/hexanes, 5 min gradient; 30 mL/min elution; 254 nm detection) to afford the title compound (0.232 g, 75% yield) as an orange solid. MS (m/z) 429.2 (M+H+).

Provenance & Evidence