反应详情

Prepared in accordance with Method B with methyl isocyanoacetate (2.51 g, 25.29 mmol) and piperazine-1-carboxylic acid tert-butyl ester (6.28 g, 33.85 mmol. The reaction mixture was stirred 1 h at RT and then concentrated. The residue was dissolved in dichloromethane (50 mL) and the organic layer was washed with 10% aqueous citric acid (2×25 mL), dried over MgSO4, filtered and evaporated. tert-Butyl 4-(2-isocyanoacetyl)piperazine-1-carboxylate SLA 07116C was obtained as a colorless oil (0.41 g, 6.5% yield).

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in dichloromethane (50 mL)
3. washthe organic layer was washed with 10% aqueous citric acid (2×25 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated