(5-Fluoropyridin-3-yl)boronic acid → HCID 178498933, compound

HRID 1423923Notes

Reaction equation

HRID 1423923 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[N:23][CH:24]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:21]1[CH:22]=[N:23][CH:24]=[C:19]([F:18])[CH:20]=1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 178498916HCID 178498916, compound

Product 1

HCID 178498933HCID 178498933, compound

Procedure

7-(5-Fluoro-pyridin-3-yl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester (Example 5e) and 5-fluoro-3-pyridyl-boronic acid under conditions analogous to Example 14(a). MS ESI(+) m/e: 332.08 (M+1).

Sources & evidence

ORD record
ord-4cd88e97130b49c59c5565f4d8f18c62
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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