3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 178498927, compound

HRID 1423924Notes

Reaction equation

HRID 1423924 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[Cl:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][C:24]=1[F:25]>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:21]1[CH:22]=[CH:23][C:24]([F:25])=[C:19]([Cl:18])[CH:20]=1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 178498916HCID 178498916, compound

Product 1

HCID 178498927HCID 178498927, compound

Procedure

7-(3-Chloro-4-fluoro-phenyl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester (Example 5e) and 3-chloro-4-fluoro-phenylboronic acid under conditions analogous to Example 7(a). MS ESI(+) m/e: 365.10 (M+1).

Sources & evidence

ORD record
ord-4550475677cb40a28ae65d9db561d46b
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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