3-Fluorophenylboronic acid → HCID 178498912, compound

HRID 1423945Notes

Reaction equation

HRID 1423945 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4].[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11]([C:23]1[CH:22]=[CH:21][CH:20]=[C:19]([F:18])[CH:24]=1)=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 178498908HCID 178498908, compound

Product 1

HCID 178498912HCID 178498912, compound

Procedure

6-(3-Fluoro-phenyl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using 3-fluoro-phenylboronic acid. 1H NMR (200 MHz, CDCl3): δ (ppm)=8.549 (s, 1H), 7.814-7.664 (m, 2H), 7.463-7.249 (m, 3H), 7.132-7.042 (m, 1H), 4.028 (s, 3H).

Sources & evidence

ORD record
ord-35061be554554d919ad9ce9c320bd30c
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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