1-Methyl-5-(tributylstannyl)-3-(trifluoromethyl)-1H-pyrazole → HCID 178498929, compound

HRID 1423958Notes

Reaction equation

HRID 1423958 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[CH3:18][N:19]1[C:23]([Sn](CCCC)(CCCC)CCCC)=[CH:22][C:21]([C:37]([F:40])([F:39])[F:38])=[N:20]1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:23]1[N:19]([CH3:18])[N:20]=[C:21]([C:37]([F:40])([F:39])[F:38])[CH:22]=1)[CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 120567101-Methyl-5-(tributylstannyl)-3-(trifluoromethyl)-1H-pyrazoleHCID 178498916HCID 178498916, compound

Product 1

HCID 178498929HCID 178498929, compound

Procedure

4-Hydroxy-7-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 44(a) using 1-Methyl-5-tributylstannanyl-3-trifluoromethyl-1H-pyrazole. The crude material was used in the next step without purification.

Workup

  1. customThe crude material was used in the next step without purification

Sources & evidence

ORD record
ord-ec778f52eb9d48c1bcb4d8990a2bdde8
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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