Potassium Phosphate, Tribasic → (8S)-8-({[t-Butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-[1-(4-pyridin-3-ylphenyl)cyclopropyl]-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

Participants

Reaction Conditions

Reaction Steps

The compound (105 mg, 0.23 mmol) obtained in Example 3-2), 3-pyridylboronic acid (31 mg, 0.25 mmol), tris(dibenzylideneacetone)dipalladium (11 mg, 0.01 mmol), tricyclohexylphosphine (8 mg, 0.03 mmol), and tripotassium phosphate (84 mg, 0.38 mmol) were dissolved in a mixed solvent of 1,4-dioxane (2 mL) and water (1 mL), and the mixture was stirred at 140° C. for 2 h under microwave irradiation. The reaction mixture was cooled to room temperature, then diluted with methylene chloride (20 mL), and separated into organic and aqueous layers by the addition of saturated aqueous sodium hydrogencarbonate (10 mL). The organic layer was washed with saturated sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (elution solvent: methanol/ethyl acetate=0% to 30%) to obtain a partially purified product (110 mg) of the title compound in a light yellow solid form.

Provenance & Evidence