Hydrochloric Acid → HCID 86712897, compound

Participants

Reaction Steps

A solution of the compound (1.35 mg, 2.5 mmol) obtained in Example 37-1) and 4 M hydrochloric acid (1,4-dioxane solution, 2.5 mL) in methanol (10 mL) was stirred at room temperature for 16 h. The reaction mixture was concentrated under reduced pressure, saturated aqueous sodium hydrogencarbonate was added to the residue, the mixture was extracted with dichloromethane, and the organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (Isco Combiflash, 12 g, methanol:ethyl acetate=0:100 to 40:60, gradient) to obtain the title compound (498 mg, 47%) as a colorless solid.

Provenance & Evidence