Hydrochloric Acid → HCID 86712962, compound

Participants

Reaction Steps

A solution of the compound (217 mg, 0.40 mmol) obtained in Example 75-1) and 4 M hydrochloric acid (1,4-dioxane solution, 2 mL) in methanol (8 mL) was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure, saturated aqueous sodium hydrogencarbonate (10 mL) was added to the residue, the mixture was extracted with ethyl acetate, and the organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by silica gel chromatography (ethyl acetate:methanol=20:80) to obtain the title compound (203 mg, quant.) as a colorless solid.

Provenance & Evidence