Hydrochloric Acid → HCID 178434523, compound

Participants

Reaction Steps

A solution of the compound (213 mg, 0.42 mmol) obtained in Example 76-1) and 4 M hydrochloric acid (1,4-dioxane solution, 3 mL) in methanol (6 mL) was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure, a 5 M aqueous sodium hydroxide solution (10 mL) was added to the residue, the mixture was extracted with ethyl acetate, and the organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by silica gel chromatography (ethyl acetate:methanol=20:80) to obtain the title compound (113 mg, 68%) as a colorless solid.

Provenance & Evidence