反应详情

A solution of the compound (591 mg, 2.23 mmol) obtained in Example 88-1) and the compound (750 mg, 2.35 mmol) obtained in Example 4-1) in t-butanol (10 mL) was stirred for 7 h under reflux conditions. The obtained reaction mixture was cooled to room temperature and concentrated under reduced pressure, and then the residue was purified by silica gel column chromatography (methanol:ethyl acetate=10:90 to 100:0) to obtain the title compound (861 mg, 70%) as a light yellow solid.

1. customThe obtained reaction mixture
2. concentrationconcentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (methanol:ethyl acetate=10:90 to 100:0)