1,4-Dioxane hydrochloride → HCID 71465953, compound

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Reaction Steps

The compound (366 mg, 0.68 mmol) obtained in Example 89-2) was dissolved in methanol (4 mL). 4 N hydrochloric acid-dioxane (1.69 mL) was added to the solution, and the mixture was stirred at room temperature for 2 h. The solvent was distilled off under reduced pressure, and the residue was separated into organic and aqueous layers with methylene chloride (150 mL) and saturated aqueous sodium hydrogencarbonate (50 mL). The organic layer was washed with saturated sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (methanol:ethyl acetate=0:100 to 20:80) to obtain the title compound (210 mg, 73%) as a white solid.

Provenance & Evidence