Trifluoroacetic acid → HCID 178462335, compound

Participants

Reaction Steps

To tert-butyl [(1R,2R)-1-(5-tert-butyl-1H-benzimidazol-2-yl)-2-hydroxypropyl]-carbamate (105 mg, 0.302 mmol) was added DCM (5 mL) followed by TFA (700 μL) at 0° C. The reaction was allowed to warm to room temperature for 4 hours before cooling back to 0° C. and quenching with saturated aqueous NaHCO3 solution (20 mL). The mixture was extracted with DCM, the organic layer collected, dried over MgSO4 and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with DCM:MeOH:NH3 (80:20:2) to afford the title compound (21 mg, 28%).

Provenance & Evidence