Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of tert-butyl [(1S)-1-(5-tert-butyl-1H-benzimidazol-2-yl)-2-hydroxy-1-methylethyl]carbamate (Preparation 26, 94 mg, 0.27 mmol) in dioxane (3 mL) was added 4M HCl in dioxane (4 mL) and the reaction stirred at room temperature for 3 hours. The reaction was concentrated in vacuo, azeotroping with toluene (2×10 mL) to afford a gummy solid. The residue was triturated with TBME (15 mL) to afford the title compound as the bis HCl salt (90 mg, 83%).

Provenance & Evidence