(4S)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid → HCID 178509555, compound

HRID 1424146Notes

Reaction equation

HRID 1424146 reaction equation
C(OC([N:8]1[C@H:12]([C:13](O)=O)[CH2:11][O:10]C1(C)C)=O)(C)(C)C.[NH2:18][C:19]1[CH:20]=[C:21]([C:26]2[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][CH:27]=2)[CH:22]=[CH:23][C:24]=1[NH2:25]>>[NH2:8][C@H:12]([C:13]1[NH:25][C:24]2[CH:23]=[CH:22][C:21]([C:26]3[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][CH:27]=3)=[CH:20][C:19]=2[N:18]=1)[CH2:11][OH:10]

Participants

3

Reactant 2

HCID 6932187(4S)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acidHCID 86699023HCID 86699023, compound

Product 1

HCID 178509555HCID 178509555, compound

Procedure

The title compound was prepared according to Method 1 using (S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The residue was purified through an SCX cartridge followed by reverse phase column chromatography eluting with 0-60% MeCN in water.

Workup

  1. customThe residue was purified through an SCX cartridge
  2. washeluting with 0-60% MeCN in water

Sources & evidence

ORD record
ord-ddfbcb6be3ba40e1ab79d9661c376352
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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