Trifluoroacetic acid → HCID 178509554, compound

Participants

Reaction Steps

To (S)-tert-butyl (1-(6-(2-chloro-4-cyanophenyl)-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate (Preparation 15, 35 mg, 0.051 mmol) was added trifluoroacetic acid (1.3 mL, 17 mmol) and the mixture stirred at room temperature for 2 hours. The reaction solution was concentrated in vacuo and azeotroped with methanol. The residue was purified using silica gel column chromatography eluting with 0-100% CMA80/methylene chloride to afford the title compound (14 mg, 65%) as a light yellow solid.

Provenance & Evidence