Water → HCID 178440696, compound

HRID 1424168Notes

Reaction equation

HRID 1424168 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH2:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH2:13]>>[NH2:11][C@@H:8]([C:9]1[NH:11][C:8]2[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:6][C:7]=2[N:12]=1)[CH2:7][CH2:6][OH:13]

Participants

3

Reactant 2

HCID 962WaterHCID 4327084-Tert-butylbenzene-1,2-diamine

Product 1

HCID 178440696HCID 178440696, compound

Procedure

The title compound was prepared using Method 4 Steps 1 and 2 followed by the method described for Example 140 using 4-tert-butyl-1,2-diaminobenzene and N-α-t-Butyloxylcarbonyl-O-benzyl-D-homoserine. The residue was diluted with water and washed with EtOAc. Dilute aqueous LiOH solution was added to pH=10 and extracted with EtOAc. The organic layer was collected, dried over Na2SO4 and concentrated in vacuo (56 mg, 79%).

Workup

  1. washwashed with EtOAc
  2. additionDilute aqueous LiOH solution was added to pH=10
  3. extractionextracted with EtOAc
  4. customThe organic layer was collected
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo (56 mg, 79%)

Sources & evidence

ORD record
ord-ea9e8c96b1b747a994c3acb3fbc3554a
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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