HCID 86699023, compound → HCID 178462332, compound

HRID 1424171Notes

Reaction equation

HRID 1424171 reaction equation
C(OC([N:8]1[C@@H:12]([C:13](O)=O)[C@@H:11]([CH3:16])[O:10]C1(C)C)=O)(C)(C)C.[NH2:19][C:20]1[CH:21]=[C:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=2)[CH:23]=[CH:24][C:25]=1[NH2:26]>>[NH2:8][C@@H:12]([C:13]1[NH:26][C:25]2[CH:24]=[CH:23][C:22]([C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=3)=[CH:21][C:20]=2[N:19]=1)[C@H:11]([OH:10])[CH3:16]

Participants

3

Reactant 2

HCID 86699023HCID 86699023, compoundHCID 86699075HCID 86699075, compound

Product 1

HCID 178462332HCID 178462332, compound

Procedure

The title compound was prepared according to Method 4 using (4R,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 59A) and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The reaction mixture was concentrated in vacuo and purified by SCX-2 cartridge (16 mg, 72%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by SCX-2 cartridge (16 mg, 72%)

Sources & evidence

ORD record
ord-940e6bbb6e86463baa1a7407ecb14986
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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