4-(Propan-2-yl)benzene-1,2-diamine → HCID 178438823, compound

HRID 1424178Notes

Reaction equation

HRID 1424178 reaction equation
C([NH:8][C@@H:9]([C:13](O)=O)[C@@H:10]([CH3:12])[OH:11])(OC(C)(C)C)=O.[CH3:16][CH:17]([C:19]1[CH:20]=[C:21]([NH2:26])[C:22]([NH2:25])=[CH:23][CH:24]=1)[CH3:18]>>[NH2:8][C@@H:9]([C:13]1[NH:25][C:22]2[CH:23]=[CH:24][C:19]([CH:17]([CH3:18])[CH3:16])=[CH:20][C:21]=2[N:26]=1)[C@H:10]([OH:11])[CH3:12]

Participants

3

Reactant 2

HCID 50970284-(Propan-2-yl)benzene-1,2-diamineHCID 6992543D-Allothreonine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)

Product 1

HCID 178438823HCID 178438823, compound

Procedure

The title compound was prepared according to Method 4 using N-Boc-D-allo-threonine (Preparation 55) and 4-(1-methylethyl)-1,2-benzenediamine. The residue was purified using preparative HPLC using the following conditions:

Workup

  1. customThe residue was purified

Sources & evidence

ORD record
ord-84a672b87f2643daad61d70a160277b6
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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