1,4-Dioxane → HCID 178496744, compound

Participants

Reaction Steps

A solution of tert-butyl {(1S,2R)-1-[(2-amino-4-bromophenyl)carbamoyl]-2-methoxypropyl}carbamate (Preparation 23, 6.5 g, 16.17 mmol) in AcOH (5 mL) was stirred at room temperature for 3 days followed by 40° C. for 18 hours. The reaction was diluted by the addition of dioxane and concentrated in vacuo. The residue was purified using reverse phase column chromatography eluting with 0-40% acetonitrile in 0.1% formic acid in water to afford the title compound as a white solid (1.8 g, 29%).

Provenance & Evidence