反应详情

To a solution of 4-neopentyl-2-nitroaniline (Preparation 88, 5.23 g, 25.1 mmol) in methanol (50 mL) was added 10% palladium on carbon (800 mg, 8 mmol) and hydrogenated at 40 psi for 3.5 hours. The mixture was filtered through celite and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with a 0-10% methanol/methylene chloride gradient to provide the title compound (2.95 g, 66%) as a purple solid.

1. filtrationThe mixture was filtered through celite and
2. concentrationconcentrated in vacuo
3. customThe residue was purified
4. washeluting with a 0-10% methanol/methylene chloride gradient