Water → HCID 86699130, compound

Participants

Reaction Steps

To a stirred solution of N-[4-(1,1-dimethylpropyl)-2-nitrophenyl]acetamide (Preparation 95, 15 g, 60 mmol) in MeOH:water (120 mL:80 mL) at 0° C. was added sodium hydroxide (5 g, 125.4 mmol) and the reaction stirred at room temperature for 18 hours. The reaction was concentrated in vacuo and extracted with EtOAc. The organic layer was collected, dried over Na2SO4 and concentrated in vacuo to afford the title compound (11 g, 88%).

Provenance & Evidence