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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1424290Generated: November 1, 2026

(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester → (+/-)-4-((3,3-Dimethylcyclobutyl)((6-fluoro-3-methylquinolin-2-yl)amino)methyl)benzoic acid

https://huagongshe.com/reaction/1424290

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl esterHCID 71243734—
Reactant(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acidHCID 71243837—
Product(+/-)-4-((3,3-Dimethylcyclobutyl)((6-fluoro-3-methylquinolin-2-yl)amino)methyl)benzoic acidHCID 71243812—

Reaction Steps

The title compound was prepared by treating (+/−)-4-[(3,3-dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester (intermediate 72) in a similar as described in the experimental for intermediate 26.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08927577B2
Source datasetuspto-grants-2015_01
ORD IDord-a168ac77dc754d7fa428d66c358d5bc4
Source noteuspto-grants-2015_01