HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trimethylbenzoic acid → HCID 24872066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trimethylbenzoic acid | HCID 10194 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 57660944 | HCID 57660944 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 24872066 | HCID 24872066 | — |
Reaction Steps
A solution of 202 mg (1.23 mmol) of 2,4,6-trimethylbenzoic acid, 467 mg (1.23 mmol) HATU, 300 mg (0.64 mmol) of (4) and 660 μl (3.85 mmol) DIPEA in 5 ml DMF were stirred at room temperature over night. The reaction mixture was diluted with 100 ml ethyl acetate, washed 3 times with 2 N NaOH/brine (2:1) and once with brine and dried over Na2SO4. The solvent was then removed under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927534B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-da657c43262647d68a683c04b91c9a9b |
| Source note | uspto-grants-2015_01 |