HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromide ion → HCID 57660935, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromide ion | HCID 259 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | tert-butyl N-(4-methylpyridin-2-yl)carbamate | HCID 11063648 | — |
| Reactant | 4-(broMoMethyl)-2-Pyrrolidinone | HCID 17948968 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57660935 | HCID 57660935 | — |
Reaction Steps
(4-Methylpyridin-2-yl)carbamic acid tert-butyl ester was alkylated with 4-bromomethylpyrrolidin-2-one by deprotonation in DMF at 0° C. with NaH and treating the sodium salt with the bromide at room temperature. After dilution of the reaction mixture with ethyl acetate and washing with saturated aqueous NaHCO3 the crude product was purified by chromatography on silica gel (ethyl acetate/hexane) to yield (14) as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927534B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ac31adea32784761bff93c5d37baa03f |
| Source note | uspto-grants-2015_01 |