4-Chlorobenzoyl chloride → HCID 66732963, compound

HRID 1424324Notes

Reaction equation

HRID 1424324 reaction equation
[CH3:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][O:7][C@H:8]2[C@H:20]([OH:21])[C@H:19]([OH:22])[C@H:18]([CH3:23])[O:17][C@@H:9]2[S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[Cl:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([O:21][C@@H:20]2[C@H:19]([O:22][C:31](=[O:32])[C:30]3[CH:34]=[CH:35][C:27]([Cl:26])=[CH:28][CH:29]=3)[C@H:18]([CH3:23])[O:17][C@H:9]([S:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[C@H:8]2[O:7][CH2:6][C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:25][CH:24]=2)=[O:32])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 66732887HCID 66732887, compound

Product 1

HCID 66732963HCID 66732963, compound

Procedure

Starting from compound of example 17 (30 g) and using 4-chlorobenzoyl chloride (26.7 ml) the title compound is obtained according to the methodology described in example 18: 50.3 g of yellow syrup.

Sources & evidence

ORD record
ord-d6bf35a460454190a8188a0cafe9e875
Source dataset
uspto-grants-2015_01
Patent number
US08927698B2

Reaction notes

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