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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1424497Generated: October 31, 2026

Trifluoroacetic acid → (1-(4-fluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methanol

https://huagongshe.com/reaction/1424497

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant3-Fluoro-2-nitropyridineHCID 2762802—
Reactant4-Fluorobutan-1-amineHCID 17863079—
Product(1-(4-fluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methanolHCID 67991782—

Reaction Steps

Intermediate 42-5 was prepared in the same manner as intermediate 11-5 using the TFA salt of 4-fluorobutan-1-amine and 3-fluoro-2-nitropyridine as starting materials.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08927720B2
Source datasetuspto-grants-2015_01
ORD IDord-7a298374d6d141f590a8b678a4952487
Source noteuspto-grants-2015_01