HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isobutylene oxide → N-Cyclopropyl-3-fluoro-N-[1-(2-hydroxy-2-methyl-propyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isobutylene oxide | HCID 11208 | — |
| Edukt | N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68290215 | — |
| Produkt | N-Cyclopropyl-3-fluoro-N-[1-(2-hydroxy-2-methyl-propyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 89940652 | — |
Reaktionsschritte
The title compound is prepared from N-cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 1,1-dimethyloxirane following a procedure analogous to that described for Intermediate 2. LC (method 2): tR=0.98 min; Mass spectrum (ESI+): m/z=402 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08927726B2 |
| Quelldatensatz | uspto-grants-2015_01 |
| ORD ID | ord-d3c887bd559f4a008e1529814455abda |
| Quellennotiz | uspto-grants-2015_01 |