Hydrochloric Acid → 5-(4-Cyanophenyl)-3-isoxazolecarboxylic acid

Participants

Reaction Steps

A mixture of 5-(4-cyano-phenyl)-isoxazole-3-carboxylic acid ethyl ester (100 mg) and 1 N aqueous NaOH solution (1.24 mL) in tetrahydrofuran (4.5 mL) is stirred at room temperature for 3 h. The reaction mixture is acidified with 3 N hydrochloric acid and concentrated in vacuo. The residue is triturated with water; the precipitate is filtered off and dried to give the title compound. LC (method 3): tR=1.01 min; Mass spectrum (ESI+): m/z=215 [M+H]+.

Provenance & Evidence