Isobutylene oxide → HCID 89940668, compound

HRID 1424529Notes

Reaction equation

HRID 1424529 reaction equation
[CH:1]1([N:4]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=3)[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:26][C:27]1([CH3:30])[O:29][CH2:28]1>>[CH:1]1([N:4]([CH:20]2[CH2:25][CH2:24][N:23]([CH2:26][C:27]([OH:29])([CH3:30])[CH3:28])[CH2:22][CH2:21]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[CH:16][CH:17]=3)[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11208Isobutylene oxideHCID 86709613HCID 86709613, compound

Product 1

HCID 89940668HCID 89940668, compound

Procedure

The title compound is prepared from 5-(4-cyano-phenyl)-isoxazole-3-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 1,1-dimethyloxirane following a procedure analogous to that described for Intermediate 2. LC (method 4): tR=1.17 min; Mass spectrum (ESI+): m/z=409 [M+H]+.

Sources & evidence

ORD record
ord-08f69533e25f4fc2a072ff1f0c4271d5
Source dataset
uspto-grants-2015_01
Patent number
US08927726B2

Reaction notes

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