HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate → 4-{[5-(4-Cyano-2-fluoro-phenyl)-isoxazole-3-carbonyl]-cyclopropyl-amino}-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate | HCID 2769591 | — |
| Reactant | 5-(4-Cyano-2-fluorophenyl)-1,2-oxazole-3-carboxylic acid | HCID 71093737 | — |
| Product | 4-{[5-(4-Cyano-2-fluoro-phenyl)-isoxazole-3-carbonyl]-cyclopropyl-amino}-piperidine-1-carboxylic acid tert-butyl ester | HCID 86709614 | — |
Reaction Steps
The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid and 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester following a procedure analogous to that described for Intermediate 6. LC (method 3): tR=1.69 min; Mass spectrum (ESI−): m/z=453 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927726B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-3e3305138171445291cf9d4ead53d094 |
| Source note | uspto-grants-2015_01 |