Isobutylene oxide → HCID 89940649, compound

HRID 1424537Notes

Reaction equation

[CH:1]1([N:4]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][C:13]=3[F:20])[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:27][C:28]1([CH3:31])[O:30][CH2:29]1>>[CH:1]1([N:4]([CH:21]2[CH2:26][CH2:25][N:24]([CH2:27][C:28]([OH:30])([CH3:31])[CH3:29])[CH2:23][CH2:22]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][C:13]=3[F:20])[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 11208Isobutylene oxide

HCID 86709616HCID 86709616, compound

Product 1

HCID 89940649HCID 89940649, compound

Procedure

The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid cyclopropyl-piperidin-4-yl-amide and 1,1-dimethyloxirane following a procedure analogous to that described for Intermediate 2. LC (method 3): tR=1.21 min; Mass spectrum (ESI+): m/z=427 [M+H]+.

Sources & evidence

ORD record: ord-4843db48c1eb49f3ab63e3cedaa4c766
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927726B2

Reaction notes

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