(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate → HCID 73053287, compound

HRID 1424541Notes

Reaction equation

HRID 1424541 reaction equation
[CH:1]1([N:4]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=3)[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1.[F:26][C:27]([F:38])([F:37])[C:28]1([CH2:31]OS(C)(=O)=O)[CH2:30][CH2:29]1>>[CH:1]1([N:4]([CH:20]2[CH2:25][CH2:24][N:23]([CH2:31][C:28]3([C:27]([F:38])([F:37])[F:26])[CH2:30][CH2:29]3)[CH2:22][CH2:21]2)[C:5]([C:7]2[CH:11]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[CH:16][CH:17]=3)[O:9][N:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 86649942(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonateHCID 86709613HCID 86709613, compound

Product 1

HCID 73053287HCID 73053287, compound

Procedure

The title compound is prepared from 5-(4-cyano-phenyl)-isoxazole-3-carboxylic acid cyclopropyl-piperidin-4-yl-amide and methanesulfonic acid (1-trifluoromethyl-cyclopropyl)methyl ester following a procedure analogous to that described for Example 3. LC (method 4): tR=1.34 min; Mass spectrum (ESI+): m/z=459 [M+H]+.

Sources & evidence

ORD record
ord-f7be1c26b78a488c8901b24555ddd0ee
Source dataset
uspto-grants-2015_01
Patent number
US08927726B2

Reaction notes

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