(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate → HCID 73050944, compound

HRID 1424542Notes

Reaction equation

HRID 1424542 reaction equation
[CH:1]1([N:4]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[C:5]([C:7]2[O:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][C:13]=3[F:20])[CH:8]=2)=[O:6])[CH2:3][CH2:2]1.[F:27][C:28]([F:39])([F:38])[C:29]1([CH2:32]OS(C)(=O)=O)[CH2:31][CH2:30]1>>[CH:1]1([N:4]([CH:21]2[CH2:26][CH2:25][N:24]([CH2:32][C:29]3([C:28]([F:39])([F:38])[F:27])[CH2:31][CH2:30]3)[CH2:23][CH2:22]2)[C:5]([C:7]2[O:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][C:13]=3[F:20])[CH:8]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 86649942(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonateHCID 86709615HCID 86709615, compound

Product 1

HCID 73050944HCID 73050944, compound

Procedure

The title compound is prepared from 3-(4-cyano-2-fluoro-phenyl)-isoxazole-5-carboxylic acid cyclopropyl-piperidin-4-yl-amide and methanesulfonic acid (1-trifluoromethyl-cyclopropyl)methyl ester following a procedure analogous to that described for Example 3. LC (method 4): tR=1.35 min; Mass spectrum (ESI+): m/z=477 [M+H]+.

Sources & evidence

ORD record
ord-0eaebd2e458f43ecbcda179dc689caf4
Source dataset
uspto-grants-2015_01
Patent number
US08927726B2

Reaction notes

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