HCID 70974557, compound → HCID 70974541, compound

HRID 1424558Notes

Reaction equation

C(OC(=O)[NH:7][CH:8]([C:26](=[O:46])[NH:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]#[C:35][C:36]2[C:41]([F:42])=[C:40]([F:43])[N:39]=[C:38]([F:44])[C:37]=2[F:45])=[CH:30][CH:29]=1)[CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:25])[CH:15]([NH:17]C(OC(C)(C)C)=O)[CH3:16])(C)(C)C.NCCCC[C@H](NC(=O)[C@@H](N)C)C(NC1C=CC(C#CC2C(F)=C(F)N=C(F)C=2F)=CC=1)=O.C(OC(=O)NCCCCC(NC(=O)C(NC(OC(C)(C)C)=O)C)C(=O)NC1C=CC(C#CC2C(F)=C(F)N=C(F)C=2F)=CC=1)(C)(C)C>>[NH2:7][C@@H:8]([CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:25])[C@@H:15]([NH2:17])[CH3:16])[C:26]([NH:27][C:28]1[CH:29]=[CH:30][C:31]([C:34]#[C:35][C:36]2[C:37]([F:45])=[C:38]([F:44])[N:39]=[C:40]([F:43])[C:41]=2[F:42])=[CH:32][CH:33]=1)=[O:46]

Participants

Reactant 3

HCID 70974557HCID 70974557, compound

HCID 70974572HCID 70974572, compound

HCID 86673526HCID 86673526, compound

Product 1

HCID 70974541HCID 70974541, compoundYield 95%

Procedure

The compound (26) was prepared from compound (25) by using the same procedure as synthesis of compound (23) from compound (22), in 95% yield; 1H NMR (400 MHz, CD3OD): 7.77 (d, J=8.7 Hz, 2H), 7.64 (d, J=8.7 Hz, 2H), 4.0 (t, J=6.6 Hz, 1H), 3.84 (q, J=7.3 Hz, 1H), 3.29-3.19 (m, 2H), 2.05-1.85 (m, 2H), 1.65-1.55 (m, 2H), 1.54-1.46 (m, 2H), 1.43 (d, J=7.3 Hz, 3H);

Sources & evidence

ORD record: ord-238713fcecf545b0957379db775793f7
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927728B2

Reaction notes

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