HCID 70974557, compound → HCID 70974524, compound

HRID 1424559Notes

Reaction equation

HRID 1424559 reaction equation
[O:1]=[C:2]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][C:30]2[C:35]([F:36])=[C:34]([F:37])[N:33]=[C:32]([F:38])[C:31]=2[F:39])=[CH:24][CH:23]=1)[C@@H:3]([NH:13]C(=O)OC(C)(C)C)[CH2:4][NH:5]C(=O)OC(C)(C)C.NCCCC[C@H](NC(=O)[C@@H](N)C)C(NC1C=CC(C#CC2C(F)=C(F)N=C(F)C=2F)=CC=1)=O>>[NH2:13][C@@H:3]([CH2:4][NH2:5])[C:2]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[C:29][C:30]2[C:35]([F:36])=[C:34]([F:37])[N:33]=[C:32]([F:38])[C:31]=2[F:39])=[CH:24][CH:23]=1)=[O:1]

Participants

3

Reactant 2

HCID 70974557HCID 70974557, compoundHCID 86673527HCID 86673527, compound

Product 1

HCID 70974524HCID 70974524, compoundYield 85%

Procedure

The compound (29) was prepared from compound (28) by using the same procedure as synthesis of compound (23) from compound (21), in 85% yield;1H NMR (400 MHz, CD3OD): 7.81 (d, J=8.5 Hz, 2H), 7.64 (d, J=8.5 Hz, 2H), 4.11 (t, J=5.8 Hz, 1H), 3.47-3.42 (m, 2H).

Sources & evidence

ORD record
ord-93eea61aaa244ef498529995cc0b851d
Source dataset
uspto-grants-2015_01
Patent number
US08927728B2

Reaction notes

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