Trifluoroacetic acid → HCID 71470362, compound

Participants

Reaction Steps

(S)-di-tert-butyl (6-((3,5-bis((perfluoropyridin-4-yl)ethynyl)phenyl)amino)-6-oxohexane-1,5-diyl)dicarbamate (0.02 g, 0.04 mmol) was reacted with neat trifluoroacetic acid (TFA) (2 mL) and the solution was stirred for 4 hours at room temperature. TFA was evaporated and the product (25 mg, 96%) was purified by recrystallization with ethanol: 1H-NMR (400 MHz, CD3OD) δ 8.08 (d, J=1.3 Hz, 2H), 7.66 (t, J=1.3 Hz, 1H), 4.10 (t, J=6.5 Hz, 1H), 2.96 (t, J=15.3 Hz, 2H), 1.94-2.10 (m, 2H), 1.73 (m, 2H), 1.57 (m, 2H), 1.30 (m, 2H).

Provenance & Evidence