Nitric Acid → 4-Aminoadamantan-1-ol

Participants

Reaction Steps

To 2-aminoadamantane (10 g, 54 mmol) was added H2SO4 (150 mL) and HNO3 (15 ml) at 0° C. and the mixture was stirred overnight. The mixture was poured onto ice and adjusted to pH=10-11 using 40% aq NaOH under ice bath. The mixture was extracted with CH2Cl2. The organic layer was dried, filtered and concentrated to give 4-aminoadamantan-1-ol (3.0 g, 14%).

Provenance & Evidence