Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

Tert-butyl 7-chloro-2-(4-methoxybenzyl)-3-thioxospiro[isoindoline-1,4′-piperidine]-1′-carboxylate (52 mg, 0.11 mmol) was dissolved in neat TFA (−2 mL): After 0.5 h LC-MS showed removal of the boc group. The mixture was evaporated to afford crude 7-chloro-2-(4-methoxybenzyl)spiro[isoindoline-1,4′-piperidine]-3-thione as its TFA salt which was used without purification.

Provenance & Evidence