HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Spiro[isoindoline-1,4'-piperidin]-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-(4-methoxybenzyl)-3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylate | HCID 58137355 | — |
| Product | Spiro[isoindoline-1,4'-piperidin]-3-one | HCID 15548169 | — |
Reaction Steps
Tert-butyl 2-(4-methoxybenzyl)-3-oxospiro[isoindoline-1,4′-piperidine]-1′-carboxylate (50 mg, 0.12 mmol, 1.0 equiv) and TFA (7 mL) were heated to 75° C. for 19 h. After this time LC-MS showed removal of the Boc- and p-methoxybenzyl groups. The mixture was concentrated to leave crude spiro[isoindoline-1,4′-piperidin]-3-one which was used directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927715B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-58852a0a1e8b42bc8ed34ccc65b659c1 |
| Source note | uspto-grants-2015_01 |