Trifluoroacetic acid → N-(2-adamantyl)spiro[indoline-3,4'-piperidine]-1'-carboxamide

Participants

Reaction Conditions

Reaction Steps

A 10-mL round-bottomed flask was charged with tert-butyl 1′-((2-adamantyl)carbamoyl)spiro[indoline-3,4′-piperidine]-1-carboxylate (50 mg, 0.107 mmol) and 20% trifluoroacetic acid in CH2Cl2 (2 mL). The mixture was stirred for 1 h at 0° C. The solution was concentrated under vacuum and the crude product was purified by preparative HPLC to provide N-(2-adamantyl)spiro[indoline-3,4′-piperidine]-1′-carboxamide (10 mg, 25%). 1H NMR (CD3OD, 400 MHz): δ=1.60˜2.00 (m, 18H), 3.00 (t, 2H), 3.86 (d, 3H), 4.08 (d, 2H), 7.40˜7.50 (m, 4H); LC-MS (4 min) tR=1.93 min, m/z=366 (M++1).

Provenance & Evidence