Ethanol → HCID 66953843, compound

HRID 1424591Notes

Reaction equation

HRID 1424591 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]([C:28]([OH:30])=[O:29])=[CH:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2.[CH2:31](O)[CH3:32]>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:15][CH2:16][C:17]3([C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:20]3)[CH2:18][CH2:19]1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 702EthanolHCID 66953672HCID 66953672, compound

Product 1

HCID 66953843HCID 66953843, compound

Procedure

A procedure analogous to that described Example 4 was followed using 1′-((2-adamantyl)carbamoyl)spiro[indene-1,4′-piperidine]-3-carboxylic acid and ethanol. 1H NMR (CD3OD) δ=1.40 (m, 5H), 1.63 (m, 2H), 1.84 (m, 8H), 1.98 (m, 5H), 2.11 (m, 2H), 3.25 (m, 2H), 3.89 (m, 1H), 4.15 (m, 2H), 4.36 (m, 2H0, 7.26 (m, 2H), 7.39 (m, 1H), 7.84 (s, 1H), 7.91 (m, 1H); LC-MS (4 min) tR=2.19 min, m/z=435.

Workup

  1. customLC-MS (4 min) tR=2.19 min, m/z=435

Sources & evidence

ORD record
ord-e0fd56c4f8464c2ca2d5cf8ea7bfcbac
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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