Ethanol → HCID 86650837, compound

HRID 1424592Notes

Reaction equation

[CH:1]12[CH2:10][CH:5]3CC(C[CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]([C:28]([OH:30])=[O:29])[CH2:20]3)[CH2:16][CH2:15]1)=[O:13])C2.[CH2:31](O)[CH3:32]>>[CH:2]1([NH:11][C:12]([N:14]2[CH2:15][CH2:16][C:17]3([C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:20]3)[CH2:18][CH2:19]2)=[O:13])[CH2:1][CH2:10][CH2:5][CH2:4][CH2:3]1

Participants

Reactant 2

HCID 702Ethanol

HCID 25063949HCID 25063949, compound

Product 1

HCID 86650837HCID 86650837, compound

Procedure

A procedure analogous to that described Example 4 was followed using 1′-((2-adamantyl)carbamoyl)-2,3-dihydrospiro[indene-1,4′-piperidine]3-carboxylic acid and ethanol. 1H NMR (CD3OD) δ=1.29 (t, 3H), 1.54 (m, 1H), 1.64 (m, 2H), 1.86 (m, 9H), 1.96 (m, 5H), 2.43 (m, 2H), 3.04 (m, 2H), 3.86 (s, 1H), 4.06 (m, 2H), 4.15 (m, 1H), 4.20 (m, 1H), 7.20 (m, 3H), 7.34 (m, 1H); LC-MS (4 min) tR=2.12 min, m/z=437.

Workup

customLC-MS (4 min) tR=2.12 min, m/z=437

Sources & evidence

ORD record: ord-f3d1053565b145a4a1543fbfa461d5e1
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927715B2

Reaction notes

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