2-adamantyl Chloroformate → HCID 25065431, compound

HRID 1424612Notes

Reaction equation

HRID 1424612 reaction equation
[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([CH:6]([CH2:16][C:17]([OH:19])=[O:18])[CH2:7][C:8]32[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=1.Cl[C:21]([O:23][CH:24]1[CH:31]2[CH2:32][CH:27]3[CH2:28][CH:29]([CH2:33][CH:25]1[CH2:26]3)[CH2:30]2)=[O:22]>>[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([CH:6]([CH2:16][C:17]([OH:19])=[O:18])[CH2:7][C:8]32[CH2:9][CH2:10][N:11]([C:21]([O:23][CH:24]2[CH:25]4[CH2:33][CH:29]5[CH2:28][CH:27]([CH2:32][CH:31]2[CH2:30]5)[CH2:26]4)=[O:22])[CH2:12][CH2:13]3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 108785372-adamantyl ChloroformateHCID 58137291HCID 58137291, compound

Product 1

HCID 25065431HCID 25065431, compound

Procedure

The title compound was prepared from 2-(6-methyl-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid and 2-adamantyl chloroformate following a procedure analogous to that described in Example 57. LC-MS Method 1 tR=2.24 min, m/z=438; 1H NMR (CDCl3) δ=7.06 (q, 2H), 6.97 (s, 1H), 4.88 (s, 1H), 4.20 (t, 2H), 3.60 (m, 1H), 3.13-2.94 (m, 3H), 2.64 (dd, 1H), 2.48 (dd, 1H), 2.35 (s, 3H).

Sources & evidence

ORD record
ord-5f4757eba81748549d7202694fb0fcfb
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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