3H-spiro[2-benzofuran-1,4'-piperidine] → HCID 25066275, compound

HRID 1424626Notes

Reaction equation

HRID 1424626 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][O:7]2)[CH2:3][CH2:2]1.[CH:15]12[CH2:24][CH:19]3[CH2:20][CH:21]([CH2:23][CH:17]([CH2:18]3)[CH:16]1[N:25]=[C:26]=[O:27])[CH2:22]2>>[CH:17]12[CH2:23][CH:21]3[CH2:20][CH:19]([CH2:24][CH:15]([CH2:22]3)[CH:16]1[NH:25][C:26]([N:1]1[CH2:6][CH2:5][C:4]3([C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH2:8][O:7]3)[CH2:3][CH2:2]1)=[O:27])[CH2:18]2

Participants

3

Reactant 2

HCID 104424983H-spiro[2-benzofuran-1,4'-piperidine]HCID 128826302-Isocyanatoadamantane

Product 1

HCID 25066275HCID 25066275, compound

Procedure

The title compound was prepared from 3H-spiro[isobenzofuran-1,4′-piperidine] following a procedure analogous to that described in Example 79 Step 2 using 2-adamantyl isocyanate in place of 2-adamantyl chloroformate. LC-MS Method 1 tR=2.03 min, m/z=367; 1H NMR (CDCl3) δ=1.60-2.00 (18H), 3.29 (m, 2H), 3.94 (m, 2H), 3.99 (s, 1H), 4.95 (1H), 5.08 (s, 2H), 7.05-7.35 (4H).

Sources & evidence

ORD record
ord-d08932f83c114164a4cdec59dbdf841e
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

Loading…