4-(Dimethylamino)butyric acid → HCID 66954086, compound

HRID 1424636Notes

Reaction equation

HRID 1424636 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][NH:21][CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2.[CH3:29][N:30]([CH3:37])[CH2:31][CH2:32][CH2:33][C:34](O)=[O:35]>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][N:21]([C:34](=[O:35])[CH2:33][CH2:32][CH2:31][N:30]([CH3:37])[CH3:29])[CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 2398204-(Dimethylamino)butyric acidHCID 25064399N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxamide

Product 1

HCID 66954086HCID 66954086, compound

Procedure

The title compound was prepared from N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine]-1′-carboxamide and 4-(dimethylamino)butanoic acid following the procedure of Example 110 Step 1. LC-MS Method 1 tR=2.4 min, m/z=493.38; 1HNMR (CD3OD) δ=1.55-1.73 (m, 4H), 1.80-1.94 (m, 8H), 1.95-2.10 (m, 8H), 2.66-2.72 (m, 2H), 2.82-2.92 (s, 6H), 3.05-3.19 (m, 2H), 3.19-3.28 (m, 2H), 3.80-3.92 (m, 1H), 3.92 (s, 3H), 3.93-4.04 (m, 1H), 4.72-4.80 (m, 2H), 5.78-5.95 (m, 1H), 7.15-7.30 (m, 3H), 7.40-7.47 (m, 1H).

Sources & evidence

ORD record
ord-c21f32dfbaa04c74af5969ca4985c02e
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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